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Article

KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells.

Molecular cancer therapeutics - 1 Jun 2014

Moran Diarmuid M, Trusk Patricia B, Pry Karen, Paz Keren, Sidransky David, Bacus Sarah S

Abstract excerpt

KRAS gene mutation is linked to poor prognosis and resistance to therapeutics in non-small cell lung cancer (NSCLC). In this study, we have explored the possibility of exploiting inherent differences in KRAS-mutant cell metabolism for treatment. This study identified a greater dependency on folate metabolism pathways in KRAS mutant compared with KRAS wild-type NSCLC cell lines. Microarray gene expression and...

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Share to Carcinoma, Non-Small-Cell Lung
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins p21(ras)

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Source

Identifiers

PMID: 24688052
DOI: 10.1158/1535-7163.MCT-13-0649

Genes

KRAS
MTHFD2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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