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Single‐cell transcriptional profiling reveals cellular senescence and inflammatory persistence as key features of type 1 diabetes partial remission

4 Apr 2025

Abstract excerpt

AIMS: To investigate the underlying immune mechanisms during partial remission (PR) in type 1 diabetes (T1D) using single-cell RNA sequencing of peripheral blood mononuclear cells from healthy controls, newly diagnosed T1D patients, and those in the PR stage. MATERIALS AND METHODS: We performed integrated analysis combining differential expression analysis, trajectory inference, cellular senescence evaluation and...

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PMID: 40183401
DOI: 10.1111/dom.16384

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