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Cross-tissue multiomics reveals that Akkermansia muciniphila counteracts metabolic syndrome by reprograming gut microbiota, oleoylethanolamide and the gut-hypothalamus axis

2022-09-08

Abstract excerpt

High fructose diet is a major risk factor for metabolic syndrome (MetS). The gut bacterium Akkermansia muciniphila (A. muciniphila) has been shown to improve fructose-induced MetS, but the underlying mechanism remains unclear. Here, we investigated how A. muciniphila modulates fructose-induced MetS using multitissue, multiomics studies encompassing gut microbiota, plasma and gut metabolome, and hypothalamus single...

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Literature Corpus work
5cc0e5a3-0342-5c05-aafc-b8cb6f7d0d2a
DOI
10.1101/2022.09.06.506855
Open publication

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Cross-tissue multiomics reveals that Akkermansia muciniphila counteracts metabolic syndrome by reprograming gut microbiota, oleoylethanolamide and the gut-hypothalamus axisDOI 10.1101/2022.09.06.506855
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