Comprehensive Molecular Analysis in NRG Oncology/RTOG 9813: A Phase 3 Study of Radiation and Temozolomide Versus Radiation and BCNU/CCNU in Anaplastic Astrocytoma.

doi:10.1016/j.ijrobp.2025.03.043

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Comprehensive Molecular Analysis in NRG Oncology/RTOG 9813: A Phase 3 Study of Radiation and Temozolomide Versus Radiation and BCNU/CCNU in Anaplastic Astrocytoma.

International journal of radiation oncology, biology, physics - 1 Sept 2025

Fleming Jessica L, Pugh Stephanie L, Chang Susan M, McElroy Joseph P, Becker Aline P, Aldape Kenneth D, Shih Helen A, Ashby Lynn Stuart, Hunter Grant K, Bahary Jean-Paul, Schultz Christopher J, Kavanagh Brian D, Puduvalli Vinay K, Robins H Ian, Werner-Wasik Maria, Mehta Minesh, Chakravarti Arnab

Abstract excerpt

PURPOSE: There is a need to better understand the molecular features that characterize grade 3 astrocytomas and their significance in predicting clinical outcomes. The aim of this study was to determine the significance of the 2021 World Health Organization (WHO)-defined molecular subgroups, along with MGMT promoter methylation, and other alterations in NRG Oncology/RTOG 9813. METHODS AND MATERIALS: Mutation...

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Identifiers

PMID: 40164352
DOI: 10.1016/j.ijrobp.2025.03.043
PMCID: PMC12857254

Genes

MGMT
ATRX
EGFR
IDH1
TERT

Provenance

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