Article
A 28nm Fully Integrated End-to-End Genome Analysis Accelerator for Next-Generation Sequencing.
IEEE transactions on biomedical circuits and systems - 1 Dec 2025
Wu Yi-Chung, Chen Yen-Lung, Yang Chung-Hsuan, Lee Chao-Hsi, Chen Wen-Ching, Lin Liang-Yi, Chang Nian-Shyang, Lin Chun-Pin, Chen Chi-Shi, Hung Jui-Hung, Yang Chia-Hsiang
Abstract excerpt
This paper presents the first end-to-end next-generation sequencing (NGS) data analysis accelerator for short-read mapping, haplotype calling, variant calling, and genotyping. It supports both single-end and paired-end short-reads (or reads) and uses the FM-index, a compact index data structure, for exact-match in short-read mapping. For inexact match part of short-read mapping, a dynamic programming array is...
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