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Article

Clonal Hematopoiesis of Indeterminate Potential and Atrial Fibrillation: Insights into Pathophysiology and Clinical Implications.

International journal of molecular sciences - 18 Mar 2025

Karakasis Paschalis, Theofilis Panagiotis, Lefkou Eleftheria, Antoniadis Antonios P, Patoulias Dimitrios, Korantzopoulos Panagiotis, Fragakis Nikolaos

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a novel risk factor for cardiovascular diseases. CHIP is characterized by the expansion of hematopoietic stem cell clones harboring somatic mutations in genes such as TET2, DNMT3A, and ASXL1, which are implicated in inflammation, atrial remodeling, and hypercoagulability. These mutations foster a pro-inflammatory and pro-thrombotic environment...

Read the complete abstract on PubMed

Topics

Humans
Atrial Fibrillation
Clonal Hematopoiesis
Mutation
Dioxygenases
Animals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Methyltransferase 3A

Repressor Proteins

DNA-Binding Proteins

Proto-Oncogene Proteins

DNA (Cytosine-5-)-Methyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 40141381
DOI: 10.3390/ijms26062739
PMCID: PMC11942860

Genes

ASXL1
TET2
DNMT3A

Provenance

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