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Article

CAUSAL ASSOCIATION BETWEEN SEPSIS AND FIBROBLAST GROWTH FACTORS AS WELL AS THEIR RECEPTORS LEVELS: A TWO-SAMPLE MENDELIAN RANDOMIZATION STUDY.

Shock (Augusta, Ga.) - 1 Jun 2025

Dai Junru, Xia Bangbo, Liu Ning, Shui Pengfei

Abstract excerpt

ABSTRACT: Objective: The potential association between sepsis risk and circulating levels of fibroblast growth factors (FGFs) and their receptors (FGFRs) has been a focus of research; however, the causal relationship between them remains to be elucidated. We hypothesize a causal association between genetically predicted FGFs, FGFRs, and sepsis risk, and we conduct a Mendelian randomization (MR) study to validate...

Read the complete abstract on PubMed

Topics

Humans
Sepsis
Mendelian Randomization Analysis
Fibroblast Growth Factors
Fibroblast Growth Factor-23
Receptors, Fibroblast Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Klotho Proteins

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 40138723
DOI: 10.1097/SHK.0000000000002565

Genes

FGFR1
FGF1
FGF16
FGF19
FGF2
FGF21
FGF23
FGF5
FGF7
FGFR2
FGFR3

Provenance

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