Reproductive Factors, Sex Hormone Levels, and Differentiated Thyroid Cancer Risk: A Mendelian Randomization Study.

doi:10.1089/thy.2024.0548

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Article

Reproductive Factors, Sex Hormone Levels, and Differentiated Thyroid Cancer Risk: A Mendelian Randomization Study.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2025

Park See Hyun, Sugier Pierre-Emmanuel, Asgari Yazdan, Karimi Mojgan, Kaaks Rudolf, Fortner Renée Turzanski, Schulze Matthias, Agnoli Claudia, Pasanisi Fabrizio, Sacerdote Carlotta, Rodriguez-Barranco Miguel, Aizpurua Amaia, Cabrera Castro Natalia, Guevara Marcela, Tin Tin Sandar, Weiderpass Elisabete, de Vathaire Florent, Lesueur Fabienne, Guénel Pascal, Mulot Claire, Laurent-Puig Pierre, Ostroumova Evgenia, Boland-Auge Anne, Deleuze Jean-François, Thomsen Hauke, Försti Asta, Elisei Rosella, Gemignani Federica, Landi Stefano, Rinaldi Sabina, Elbaz Alexis, Domenighetti Cloé, Truong Thérèse

Abstract excerpt

Background: Differentiated thyroid carcinoma (DTC) is occurring three times more frequently in females than in males. However, the underlying biological mechanisms driving this discrepancy remain poorly understood. To investigate the causal role of sex hormones and reproductive factors in the risk of DTC, we implemented a two-sample Mendelian randomization (MR) analysis. Methods: We utilized genome-wide...

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PMID: 40137860
DOI: 10.1089/thy.2024.0548

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