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Druggable Molecular Networks in BRCA1/BRCA2-Mutated Breast Cancer

2 Mar 2025

Abstract excerpt

Mutations in the tumor suppressor genes BRCA1 and BRCA2 are associated with the triple-negative breast cancer phenotype, particularly aggressive and hard-to-treat tumors lacking estrogen, progesterone, and human epidermal growth factor receptor 2. This research aimed to understand the metabolic and genetic links behind BRCA1 and BRCA2 mutations and investigate their relationship with effective therapies. Using...

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PMID: 40136510
DOI: 10.3390/biology14030253

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