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Article

Genetic variants in insulin, leptin, and their receptors are associated with overweight in a Brazilian asthma cohort.

Nutrition research (New York, N.Y.) - 1 Apr 2025

Coelho Raísa, Cruz Álvaro A, Lima Louise, Melo Ana Paula, Belitardo Emília, Machado Candace, Fernandes Jamille Souza, Costa Gustavo Nunes de Oliveira, Souza-Machado Adelmir, Pinheiro Gabriela Pimentel, Santana Cinthia Vila Nova, Figueiredo Camila Alexandrina, Costa Ryan Dos S

Abstract excerpt

Obesity is often characterized by meta-inflammation and is influenced by the interaction between genetic predisposition and environmental factors. Common features include impaired insulin action and elevated leptin concentrations, which are accompanied by a simultaneous reduction in sensitivity to these hormones. We hypothesized that single nucleotide variants in protein-coding genes and their receptors may...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40132274
DOI: 10.1016/j.nutres.2025.01.012

Genes

INS
INSR
LEP
LEPR

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