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Article

Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma.

British journal of cancer - 11 Oct 2011

Sturla L-M, Zinn P O, Ng K, Nitta M, Kozono D, Chen C C, Kasper E M

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) signalling is frequently altered during glioblastoma de novo pathogenesis. An important downstream modulator of this signal cascade is SHP2 (Src homology domain-containing phosphatase 2). METHODS: We examined the The Cancer Genome Atlas (TCGA) database for SHP2 mutations. We also examined the expression of a further 191 phosphatases in the TCGA database and used...

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Source

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Identifiers

PMID: 21934682
DOI: 10.1038/bjc.2011.345
PMCID: PMC3208488

Genes

EGFR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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