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Development and validation of an ovarian cancer risk assessment tool for first-degree relatives of patients in the Chinese population.

Gynecologic oncology - 1 Apr 2025

Li Yuan, Wu Manqi, Liu Qiyu, Huang Cuiyu, Fan Yiming, Wang Mengyang, Jin Yikun, Tao Liyuan, Yang Xielan, Guo Hongyan

Abstract excerpt

OBJECTIVE: To develop and validate an ovarian cancer risk assessment tool for first-degree relatives of patients in the Chinese population. METHODS: A bidirectional multicenter cohort was established, including 529 probands and 3141 first-degree relatives. Cancer incidence was analyzed using the standardized incidence ratio (SIR). Significant variables were identified through Cox regression analyses and...

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PMID: 40117943
DOI: 10.1016/j.ygyno.2025.03.017

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