Impact of switching antiplatelet therapy in acute coronary syndrome patients with different CYP2C19 phenotypes: insights from a single-center study.

doi:10.1097/FPC.0000000000000564

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Impact of switching antiplatelet therapy in acute coronary syndrome patients with different CYP2C19 phenotypes: insights from a single-center study.

Pharmacogenetics and genomics - 1 Jul 2025

Senguttuvan Nagendra Boopathy, Ramamurthy Muralidharan Thoddi, Kumar Nithesh, Kumar Pavitraa Saravana, Chidambaram Yogapriya, Kasi Madhesh, Karthikeyan Gautam Ganesan, Anandaram Asuwin, Kidambi Bharath Raj, Shanmugasundram Sadhanandham, Panchanatham Manokar, Anjanappa Rammurthy, Seenappa Venu, Venkatesan Vettriselvi, Sankaran Ramesh, Sadagopan Thanikachalam

Abstract excerpt

OBJECTIVE: Optimizing antiplatelet therapy is crucial in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary interventions (PCIs). This study aimed to assess the prevalence of CYP2C19 loss-of-function (LOF) variants and evaluate the clinical outcome of ticagrelor, clopidogrel, and aspirin in patients with ACS-PCI. METHODS: This study included patients from the southern part of India...

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PMID: 40112230
DOI: 10.1097/FPC.0000000000000564

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CYP2C19

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