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Article

Outcomes of Ticagrelor Versus High-dose Clopidogrel in CYP2C19 Intermediate Metabolizer Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndromes.

Journal of cardiovascular pharmacology - 1 Sept 2024

Huang Hui-Min, Ran Feng-Ying, Chen Jun, Shen Yu-Si, Liu Ning, Jiang Xue-Qiang, Wang Yue

Abstract excerpt

ABSTRACT: Guidelines on antiplatelet recommendation for CYP2C19 intermediate metabolizer (IM) have not come to an agreement. This study aimed to evaluate the clinical benefit of ticagrelor when compared with high-dose clopidogrel in CYP2C19 IM after percutaneous coronary intervention for acute coronary syndromes. Patients were enrolled according to CYP2C19 genotype and individual antiplatelet therapy. Patient...

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Acute Coronary Syndrome
Clopidogrel
Cytochrome P-450 CYP2C19
Hemorrhage
Percutaneous Coronary Intervention

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenomic Variants

Platelet Aggregation Inhibitors

Source

Identifiers

PMID: 39240730
DOI: 10.1097/FJC.0000000000001582

Genes

CYP2C19

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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