Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer's disease.

doi:10.1186/s13195-025-01711-z

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Article

Tau-PET pathology in the subregions of the amygdala and its associations with cognitive performance and neuropsychiatric symptoms in autosomal dominant Alzheimer's disease.

Alzheimer's research & therapy - 20 Mar 2025

Tristão-Pereira Catarina, Langella Stephanie, Sanchez Justin S, Malotaux Vincent, He Bing, Alcina Jorge, Martinez Jairo E, Rubinstein Zoe, Baena Ana, Vila-Castelar Clara, Giudicessi Averi, Ramirez Gomez Liliana, Ramos Claudia, Vasquez Daniel, Aguillon David, Jacobs Heidi I L, Sperling Reisa A, Johnson Keith, Gatchel Jennifer R, Quiroz Yakeel T

Abstract excerpt

BACKGROUND: The amygdala plays a role in behavior and emotional response and is vulnerable to Alzheimer's disease (AD) pathology, yet little is known about amygdala tau accumulation before clinical symptom onset. To investigate whether certain amygdala nuclei are particularly vulnerable to degeneration and might underlie early neuropsychiatric symptoms in AD, we aimed to characterize subregional amygdala tau...

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PMID: 40108701
DOI: 10.1186/s13195-025-01711-z
PMCID: PMC11924723

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