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Article

Serine/threonine kinase 11 (STK11) associated adnexal tumors: from biology to therapeutic impact.

Human genomics - 18 Mar 2025

Huang Guanxiang, Lin Wenyu, Jiang Tingting, Cai Yuanjun, Lin Chengbin, Sun Pengming

Abstract excerpt

Female adnexal malignancies, while relatively uncommon, exhibit high mortality rates due to often-late diagnosis. The serine/threonine kinase 11 (STK11) is a tumor suppressor gene, and its inactivation or mutation often leads to an autosomal dominant genetic disorder known as Peutz-Jeghers syndrome (PJS), which is associated with ovarian and cervical cancers. STK11-associated adnexal tumors mostly originate from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40102938
DOI: 10.1186/s40246-025-00741-w
PMCID: PMC11921566

Genes

STK11
MISP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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