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Article

Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis.

Rheumatology (Oxford, England) - 1 Jun 2025

Riley Thomas R, Wheeler Austin M, Cannon Grant W, Sauer Brian, Wysham Katherine D, England Bryant R, Wipfler Kristin, Michaud Kaleb, March Michael, Damrauer Scott M, Verma Anurag, George Michael D, Mikuls Ted R, Baker Joshua F

Abstract excerpt

OBJECTIVES: In patients with RA, we evaluated a single-nucleotide variant previously associated with lower CRP to assess if this impacts clinical disease activity assessments including the disease activity score-28 with CRP (DAS28(CRP)). METHODS: Patients from three observational cohorts were evaluated-the United Kingdom Biobank (UKB), the Veterans Affairs RA Registry (VARA) and the FORWARD Databank. The effect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40100756
DOI: 10.1093/rheumatology/keaf069
PMCID: PMC12107066

Genes

CRP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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