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Gene-environment interaction modifies the association between hyperinsulinemia and serum urate levels through SLC22A12

18 Mar 2025

Abstract excerpt

BACKGROUNDHyperinsulinemia and insulin resistance often accompany elevated serum urate levels (hyperuricemia), a highly heritable condition that triggers gout; however, the underlying mechanisms are unclear.METHODSWe evaluated the association between the index of hyperinsulinemia and the fractional excretion of urate (FEUA) in 162 outpatients. The underlying mechanisms were investigated through single-cell data...

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Share to Alcohol Consumption and Health Effects
Share to Gout, Hyperuricemia, Uric Acid
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PMID: 40100301
DOI: 10.1172/jci186633

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