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Loss of BCL7A permits IRF4 transcriptional activity and cellular growth in multiple myeloma

16 Mar 2025

Abstract excerpt

ABSTRACT: Multiple myeloma (MM) is a complex hematological malignancy characterized by genomic changes and transcriptomic dysregulation. Initial exome sequencing approaches have failed to identify any single, frequent (>25%) mutation in the coding genome. However, using whole-genome sequencing, we found that one of the genomic regions most frequently mutated (62% of the patients with MM) was the 5' untranslated...

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PMID: 40090008
DOI: 10.1182/blood.2024026588

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