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Article

Generation of stable brain cell cultures from embryonic zebrafish to interrogate phenotypes in zebrafish mutants of neurodevelopmental disorders.

Journal of neuroscience methods - 1 Jun 2025

Odierna G Lorenzo, Stednitz Sarah, Pruitt April, Arnold Joshua, Hoffman Ellen J, Scott Ethan K

Abstract excerpt

BACKGROUND: Zebrafish are a popular model system to study the genetic and neural basis of perception and behavior. Cultured primary neurons provide a complementary tool for such studies, but existing protocols for culturing embryonic zebrafish neurons are limited by short cell survival and low neuronal purity. In this study, we set out to establish a protocol to produce long lived brain cell cultures from...

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PMID: 40086601
DOI: 10.1016/j.jneumeth.2025.110426

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