Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insight into the inhibitory activity of mangiferin and Silybin against HER2 and EGFR using theoretical and experimental approaches

13 Mar 2025

Abstract excerpt

Despite the advances made in diagnosing and treating breast cancer, it continues to pose a significant threat to women's health. High-risk mutations can lead to high resistance to current treatments and poor prognosis. Therefore, new treatment strategies are needed. Mangiferin and silybin, two natural substances obtained from plants, have demonstrated encouraging results as anticancer drugs. This study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Metabolism, Diabetes, and Cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40082669
DOI: 10.1038/s41598-025-93612-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insight into the inhibitory activity of mangiferin and Silybin against HER2 and EGFR using theoretical and experimental approachesPMID 40082669Read ↗

Exploring Moringa oleifera Phytochemicals as Potential Inhibitors for HIF- 1α/VEGF/GLUT1 pathway in Breast Cancer Using Molecular Docking, MD Simulations, and DFT AnalysisSemantic proximity Read ↗

Screening and identification of phytochemical drug molecules against mutant BRCA1 receptor of breast cancer using computational approaches.Semantic proximity Read ↗

Structure-based virtual screening, pharmacokinetic prediction, molecular dynamics studies for the identification of novel EGFR inhibitors in breast cancerSemantic proximity Read ↗

Molecular docking and MD simulation approach to identify potential phytochemical lead molecule against triple negative breast cancerSemantic proximity Read ↗

Protein-Ligand Based Pharmacophore Approach against ERK5 Involved in Breast Cancer; In-Silico Study of Flavonoids from Blighia sapidaSemantic proximity Read ↗

Uncovering the Natural Inhibitors From Medicinal Plants to Alleviate Human Cancers Targeting the p53 Protein: An In Silico ApproachSemantic proximity Read ↗

Design, synthesis, molecular docking and molecular dynamics studies of some 3-methoxy flavone derivatives as an anti-breast cancer agentSemantic proximity Read ↗

Integrated virtual screening and molecular dynamics simulation approaches revealed potential natural inhibitors for DNMT1 as therapeutic solution for triple negative breast cancerSemantic proximity Read ↗

A drug design strategy based on molecular docking and molecular dynamics simulations applied to development of inhibitor against triple-negative breast cancer by Scutellarein derivativesSemantic proximity Read ↗

Cell cycle arrest and apoptotic studies of Terminalia chebula against MCF-7 breast cancer cell line: an in vitro and in silico approachSemantic proximity Read ↗

Computational evaluation of Fenugreek-derived compounds as FGFR2 inhibitors for cancer therapySemantic proximity Read ↗

In silico screening and identifying phytoconstituents of Withania somnifera as potent inhibitors of BRCA1 mutants: A therapeutic against breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.