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Design, synthesis, molecular docking and molecular dynamics studies of some 3-methoxy flavone derivatives as an anti-breast cancer agent

15 May 2025

Abstract excerpt

The present study aimed to synthesize flavone hybrids with 3-methoxy substitution and an N -heterocyclic ring at the 4ʹ position of the flavone B ring and test their effectiveness against cancer. Molecular docking of 3-methoxy flavone was studied on ER-α and EGFR. By cyclizing chalcones, various flavonol derivatives were synthesized and 3-methoxy flavones were produced by flavonol methylation. 3-methoxy flavone...

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PMID: 40374975
DOI: 10.1007/s12672-025-02491-6

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