Article
Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.
Biochemical and biophysical research communications - 13 Aug 2020
Lee Yeunkum, Zhang Yinhua, Kang Hyojin, Bang Geul, Kim Yoonhee, Kang Hyae Rim, Ma Ruiying, Jin Chunmei, Kim Jin Young, Han Kihoon
Abstract excerpt
Variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) gene are associated with early-onset epileptic encephalopathy, intellectual disability, and developmental delay. However, the current understanding of the molecular functions of CYFIP2 is limited to those related to actin dynamics, and thus, the detailed mechanisms of CYFIP2-associated brain disorders remain largely unknown. Here, we isolated the...
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