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Single-cell transcriptome analysis reveals cellular heterogeneity in the aortas of Takayasu arteritis

10 Mar 2025

Abstract excerpt

OBJECTIVES: Takayasu arteritis (TAK) is an inflammatory vasculitis that affects the aorta and its primary branches. The pathogenesis of TAK remains elusive, yet identifying key cell types in the aorta of TAK patients is crucial for uncovering cellular heterogeneity and discovering potential therapeutic targets. METHODS: This study utilized single-cell transcriptome analysis on aortic specimens from three TAK...

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PMID: 40065428
DOI: 10.1186/s13075-025-03523-w

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