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A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

10 Mar 2025

Abstract excerpt

PTEN-induced kinase-1 (PINK1) is a crucial player in selective clearance of damaged mitochondria via the autophagy-lysosome pathway, a process termed mitophagy. Previous studies on PINK1 mainly focused on its post-translational modifications, while the transcriptional regulation of PINK1 is much less understood. Herein, we reported a novel mechanism in control of PINK1 transcription by SMAD Family Member 3...

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PMID: 40064862
DOI: 10.1038/s41421-025-00774-4

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