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Article

Association of XRCC gene family and CDH1 gene polymorphisms with gastric cancer risk in a Chinese population.

Personalized medicine - 1 Apr 2025

Sun Yalan, Wang Ying, Xiong Mengqiu, Tai Ping, Nasifu Lubanga, Cho William Chi Shing, Zhu Chengbin, Hou Panfei, He Bangshun

Abstract excerpt

BACKGROUND: Gastric carcinogenesis is associated with defects in DNA damage repair pathways, in which the XRCC gene family (XRCC1, XRCC5, and XRCC6) play an important role in DNA repair. It is also well known that the CDH1 gene, as a tumor suppressor, influences the development of gastric cancer. METHODS: We recruited 484 gastric cancer patients and 471 controls. DNA genotyping and Helicobacter pylori infection...

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Identifiers

PMID: 40059436
DOI: 10.1080/17410541.2025.2473306

Genes

XRCC1
CDH1
XRCC5
XRCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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