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Zebrafish as a model organism in One Health Toxicology: Impact of solvents and exposure routes on the toxicity of platinum anticancer drugs

23 Feb 2025

Abstract excerpt

• Cisplatin dissolved in physiological NaCl solution instead of conventional E3 medium exerts decreased lethality. • The common solvent DMSO enhances cisplatin toxicity and bioavailability. • Cisplatin provokes edema formation only when administered by microinjection into the blood stream. • The higher toxicity of cisplatin compared to oxaliplatin and carboplatin in humans can be recapitulated in zebrafish...

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PMID: 40058302
DOI: 10.1016/j.envint.2025.109349

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