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Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells

8 Mar 2025

Abstract excerpt

Cervical cancer is the fourth most common female cancer, with the uterine ectocervix being the most commonly affected site. However, cervical stem cells, their differentiation, and their regulation remain poorly understood. Here, we report the isolation of a population enriched for human cervical stem cells and their regulatory mechanisms. Using single-cell RNA sequencing, we characterize the cellular...

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PMID: 40057497
DOI: 10.1038/s41467-025-57323-6

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