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Article

Purifying selection of the lysosomal enzymes arylsulfatase A and beta-galactocerebrosidase and their evolutionary impact on myelin integrity.

Journal of lipid research - 1 Apr 2025

Luetzen Matthew A, Chakraborty Richik, Moreno-Ramos Oscar Andrés, Echeverri-Peña Olga Yaneth, Satta Yoko, Montaño Adriana M

Abstract excerpt

The myelin is responsible for providing stability to the axons of the nerve cells, but above all, to improve transmission speed of the nerve impulse in vertebrates. Over 70% of the myelin sheath is composed of lipids and the remaining portion by approximately 2,000 proteins. The myelin sheath has been constantly evolving, and it is known that unusually high concentrations of galactosylceramide (GalCer) and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40054667
DOI: 10.1016/j.jlr.2025.100769
PMCID: PMC12008523

Genes

ARSA
GALC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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