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Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship

20 Sept 2005

Abstract excerpt

Sulfatases catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates. Several human inherited diseases are caused by the deficiency of individual sulfatases, while in patients with multiple sulfatase deficiency mutations in the Sulfatase Modifying Factor 1 (SUMF1) gene cause a defect in the post-translational modification of a cysteine residue into C(alpha)-formylglycine (FGly) at the...

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PMID: 16174644
DOI: 10.1093/hmg/ddi351

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