Ribosome specialization by cancer-associated ribosomal protein mutations: progress made and open questions.

Abstract excerpt

Congenital mutations in ribosomal proteins (RPs) cause Diamond-Blackfan anaemia (DBA) syndrome. Whereas DBA patients suffer from anaemia and disease symptoms owing to a lack of cell proliferation (hypo-proliferation) early in life, they have a significantly elevated risk of developing cancer (a disease of hyper-proliferation) at a later age. The association between ribosome defects and cancer is further...

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