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Circulating mitochondrial DNA signature in cardiometabolic patients

5 Mar 2025

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction is a hallmark of cardiometabolic diseases. Circulating mitochondrial DNA (mtDNA) profiles could refine risk stratification, but current methods do not account for different fractions of circulating mtDNA. We investigated whether patients with type 2 diabetes and/or heart failure (HF) have a specific signature of the total circulating mtDNA profile, including intracellular and...

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PMID: 40045401
DOI: 10.1186/s12933-025-02656-1

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