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LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment

4 Mar 2025

Abstract excerpt

Lipid nanoparticle (LNP)-mRNA vaccines have demonstrated protective capability in combating SARS-CoV-2. Their extensive deployment across the global population leads to the broad presence of T-cell immunity against the SARS-CoV-2 spike protein, presenting an opportunity to harness this immunological response as a universal antigen target for cancer treatment. Herein, we design and synthesize a series of amino...

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PMID: 40038251
DOI: 10.1038/s41467-025-57149-2

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