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Tuning the tropism and infectivity of SARS-CoV-2 virus-like particles for mRNA delivery

27 Feb 2025

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus-like particles (VLPs) are ∼100-nm-sized bioinspired mimetics of the authentic virus. We undertook molecular engineering to optimize the VLP platform for messenger RNA (mRNA) delivery. Cloning the nucleocapsid protein upstream of M-IRES-E resulted in a three-plasmid (3P) VLP system that displayed ∼7-fold higher viral entry efficiency compared with...

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PMID: 40037714
DOI: 10.1093/nar/gkaf133

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