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Article

The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model.

Human molecular genetics - 15 Dec 2015

de Waal Eric, Vrooman Lisa A, Fischer Erin, Ord Teri, Mainigi Monica A, Coutifaris Christos, Schultz Richard M, Bartolomei Marisa S

Abstract excerpt

Assisted reproductive technologies (ART) are associated with several complications including low birth weight, abnormal placentation and increased risk for rare imprinting disorders. Indeed, experimental studies demonstrate ART procedures independent of existing infertility induce epigenetic perturbations in the embryo and extraembryonic tissues. To test the hypothesis that these epigenetic perturbations persist...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26401051
DOI: 10.1093/hmg/ddv400
PMCID: PMC4654053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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