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Rapid and high-sensitivity screening of pregnancy complications by profiling circulating placental extracellular vesicles

26 Feb 2025

Abstract excerpt

Herein, we developed a specific, rapid sensor to quantify placental extracellular vesicle (EV) protein biomarkers of early pregnancy complications. A distinct tetraspanin CD9 and placental alkaline phosphatase (PLAP) expression pattern was observed via targeted multiple reaction monitoring of EVs from maternal plasma collected before 18 weeks of gestation. A classification model was developed using training and...

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PMID: 40009685
DOI: 10.1126/sciadv.adr4074

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