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Novel regulators of GVHD revealed through microbiome and metabolome patterns across distinct intestinal regions

26 Feb 2025

Abstract excerpt

ABSTRACT: Microbial dysbiosis and metabolite changes in the gastrointestinal (GI) tract have been linked to pathogenesis and severity of many diseases, including graft-versus-host disease (GVHD), the major complication of allogeneic hematopoietic stem cell transplantation. However, published studies have only considered the microbiome and metabolome of excreted stool and do not provide insight into the...

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PMID: 40009444
DOI: 10.1182/blood.2024025924

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