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Article

Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severity

30 Apr 2020

Abstract excerpt

Acute graft-versus-host disease (aGVHD) is the main complication of hematopoietic stem cell transplantation (HSCT). Changes in gut microbiota composition have been associated with subsequent aGVHD, and reconstitution of healthy microbiota is currently being explored as a therapeutic approach. However, the specific actors in the intestinal ecosystem involved in the pathologic process at the time of aGVHD onset are...

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PMID: 32353108
DOI: 10.1182/bloodadvances.2020001531

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