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Article

Diabetes-induced glucolipotoxicity impairs wound healing ability of adipose-derived stem cells-through the miR-1248/CITED2/HIF-1α pathway.

Aging - 15 Apr 2020

Xiao Shune, Zhang Dan, Liu Zhiyuan, Jin Wenhu, Huang Guangtao, Wei Zairong, Wang Dali, Deng Chengliang

Abstract excerpt

Despite being an attractive cell type for mesenchymal stem cell (MSC) transplantation therapy for wound healing, human adipose-derived stem cells (hADSCs) from diabetes mellitus (DM) patients result in remarkable retention of stem cell activity due to diabetes-induced glucolipotoxicity. We explored the effect of diabetes and medium containing AGEs on the cell activity, phenotype, multipotency, angiogenic...

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Source

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Identifiers

PMID: 32294623
DOI: 10.18632/aging.103053
PMCID: PMC7202540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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