Targeting Chk1 and Wee1 kinases enhances radiosensitivity of 2D and 3D head and neck cancer models to X-rays and low/high-LET protons

Abstract excerpt

Abstract Ionising radiation causes the introduction of DNA damage, more specifically double strand breaks (DSBs) and complex DNA damage (CDD), that induces cancer cell death leading to the therapeutic effect. To combat this, cells activate arrest at the G2/M checkpoint to allow for effective DNA damage repair, coordinated by the Chk1 and Wee1 protein kinases. Therefore, Chk1 and Wee1 are considered promising...

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