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Hippocampal Granule Cells Downregulate Their GABAergic Phenotype and Deactivate Its Activity-Dependent Reinduction in Culture Conditions.

Synapse (New York, N.Y.) - 1 Mar 2025

Gómez-Lira Gisela, Castro Héctor, Reyes-Vaca Arturo, Gutiérrez Rafael

Abstract excerpt

Hippocampal granule cells express GABAergic and glutamatergic phenotype markers during development; hence, they corelease GABA and glutamate. In the adult, the GABAergic phenotype is switched off; however, increased excitability upregulates the GABAergic phenotype and thus, granule cells corelease glutamate and GABA. Previous work shows that short-term cultures (24 h) of dissociated granule cells prepared from...

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PMID: 39981982
DOI: 10.1002/syn.70012

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BDNF

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