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Article

Yes-associated protein plays oncogenic roles in human sporadic colorectal adenomas.

Carcinogenesis - 20 Jan 2025

Fan Lei, Guo Xingyi, Washington Mary K, Shi Jiajun, Ness Reid M, Liu Qi, Wen Wanqing, Huang Shuya, Liu Xiao, Cai Qiuyin, Zheng Wei, Coffey Robert J, Shrubsole Martha J, Su Timothy

Abstract excerpt

The role of Hippo-Yes-associated protein (YAP) in human colorectal cancer (CRC) presents contradictory results. We examined the function of YAP in the early stages of CRC by quantitatively measuring the expression of phospho-YAPS127 (p-YAP) and five APC-related proteins in 145 sporadic adenomas from the Tennessee Colorectal Polyp Study, conducting APC sequencing for 114 adenomas, and analyzing YAP-correlated...

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Identifiers

PMID: 39977302
DOI: 10.1093/carcin/bgaf007
PMCID: PMC11923420

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APC

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