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Remdesivir is active in vitro against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase.

Infectious diseases (London, England) - 1 Jul 2025

Nyström Kristina, Trybala Edward, Said Joanna, Roth Anette, Patzi Churqui Marianela, Kärmander Ambjörn, Cihlar Tomas, Bilello John P, Bergström Tomas, Lagging Martin

Abstract excerpt

BACKGROUND: Tick-borne encephalitis (TBE) is a neurological disease caused by the tick-borne encephalitis virus (TBEV). Despite available vaccines, breakthrough infections occur, some fatal. OBJECTIVES: As no antiviral therapy for TBE is currently approved, this study evaluated the in vitro activity of already licenced remdesivir (RDV) and sofosbuvir (SOF) for possible drug repurposing against TBEV. METHODS: TBEV...

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PMID: 39973341
DOI: 10.1080/23744235.2025.2468510

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