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Article

Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro.

Antiviral research - 1 Mar 2020

Dragoni Filippo, Boccuto Adele, Picarazzi Francesca, Giannini Alessia, Giammarino Federica, Saladini Francesco, Mori Mattia, Mastrangelo Eloise, Zazzi Maurizio, Vicenti Ilaria

Abstract excerpt

Sofosbuvir, a licensed nucleotide analog targeting hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), has been recently evaluated as a broad anti-Flavivirus lead candidate revealing activity against Zika and Dengue viruses both in vitro and in animal models. In this study, the in vitro antiviral activity of sofosbuvir against West Nile virus (WNV) was determined by plaque assay (PA) and Immunodetection...

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Identifiers

PMID: 31931104
DOI: 10.1016/j.antiviral.2020.104708

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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