Article
M49L and other drug resistance mutations emerging in individuals after administration of ensitrelvir in Japanese clinical settings.
Antiviral research - 1 Apr 2025
Inoue Akira, Ichikawa Takaya, Wada Daiki, Maruyama Shuhei, Shimazu Haruka, Kashihara Masami, Okuda Kazuyuki, Saito Fukuki, Fukuhara Takasuke, Nakamori Yasushi
Abstract excerpt
Recent in-vitro and in-vivo studies and analysis of genomic information registered in GISAID have raised concerns about drug resistance mutations such as M49L after treatment with the 3C-like protease inhibitor ensitrelvir. The aim of this study was to identify resistance gene mutations to 3C-like protease inhibitors, including M49L mutations, in Japanese clinical settings. Genomic analysis of samples from our...
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