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Article

Risk of major adverse cardiovascular events in CYP2C19 LoF genotype guided clopidogrel against alternative antiplatelets for CAD patients undergoing PCI: Meta-analysis.

Clinical and translational science - 1 Feb 2025

Biswas Mohitosh, Murad Murshadul Alam, Ershadian Maliheh, Kali Most Sumaiya Khatun, Sukasem Chonlaphat

Abstract excerpt

Selection of rational antagonists of P2Y12 receptor for CAD patients who inherit CYP2C19 LoF alleles remains still conflicting. This study compared the clinical outcomes in CAD patients inheriting CYP2C19 LoF alleles undergoing PCI and treated with clopidogrel against alternative antagonists of P2Y12 receptor. A thorough literature search was performed across multiple scientific databases following the PRISMA...

Read the complete abstract on PubMed

Topics

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Share to Clopidogrel
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Percutaneous Coronary Intervention

Share to Platelet Aggregation Inhibitors

Share to Prasugrel Hydrochloride

Share to Purinergic P2Y Receptor Antagonists

Share to Ticagrelor

Source

Open in PubMed Open full text

Identifiers

PMID: 39953666
DOI: 10.1111/cts.70080
PMCID: PMC11828747

Genes

CAD
CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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