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Article

Navigating variants of uncertain significance in genetic dyslipidemia: how to assess and counsel patients.

Current opinion in lipidology - 1 Apr 2025

Ison Hannah E, Helm Benjamin, Kringlen Gabriel, Crawford Paul

Abstract excerpt

PURPOSE OF REVIEW: Genetic testing has become an integral component of clinical care when an inherited condition is suspected. However, the interpretation of variants identified with this testing can be nuanced. Variants of uncertain significance (VUS) are variants for which there is not enough data currently available to determine if the variant is causal for disease (i.e. pathogenic) or is benign. VUS can exist...

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PMID: 39950242
DOI: 10.1097/MOL.0000000000000971

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