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Article

Interpretation of Incidental Genetic Findings Localizing to Genes Associated With Cardiac Channelopathies and Cardiomyopathies.

Circulation. Genomic and precision medicine - 1 Aug 2021

Ezekian Jordan E, Rehder Catherine, Kishnani Priya S, Landstrom Andrew P

Abstract excerpt

Recent advances in next-genetic sequencing technology have facilitated an expansion in the use of exome and genome sequencing in the research and clinical settings. While this has aided in the genetic diagnosis of individuals with atypical clinical presentations, there has been a marked increase in the number of incidentally identified variants of uncertain diagnostic significance in genes identified as...

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PMID: 34384235
DOI: 10.1161/CIRCGEN.120.003200
PMCID: PMC8375606

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