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Article

Causal relationship between inflammatory bowel disease and sex: a Mendelian randomization study.

Frontiers in endocrinology - 1 Jan 2025

Wang Kaiwen, Lou Yu, Tian Shunjie, Tao Zhihui

Abstract excerpt

Objective: The aim of this study was to investigate the bidirectional causal relationship between sex hormones and IBD through a two-sample bidirectional Mendelian randomization (MR) study. Methods: Based on Genome-Wide Association Study (GWAS) pooled data on SHBG, total testosterone, bioavailable testosterone, estradiol, and IBD in a European population, we performed two-sample bidirectional MR analyses using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39944207
DOI: 10.3389/fendo.2025.1338701
PMCID: PMC11813775

Genes

SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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