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HSP90 co-regulates the formation and nuclear distribution of the glycolytic output complex to promote resistance and poor prognosis in gastric cancer patients

10 Feb 2025

Abstract excerpt

BACKGROUND: Resistance to treatment is a critical factor contributing to poor prognosis in gastric cancer patients. HSP90 has emerged as a promising therapeutic target; however, its role in regulating tumor metabolic pathways, particularly glycolysis, remains poorly understood, which limits its clinical application. METHODS: We identified proteins that directly interact with HSP90 using immunoprecipitation (IP)...

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PMID: 39930487
DOI: 10.1186/s12967-025-06196-w

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